Insight into Rare Structurally Characterized Homotrinuclear CuII Non-Symmetric Salamo-Based Complex

A Structurally Characterized Organometallic Plutonium(IV) Complex

The blood-red plutonocene complex Pu(1,3-COT'')(1,4-COT'') (4; COT''=η8 -bis(trimethylsilyl)cyclooctatetraenyl) has been synthesized by oxidation of the anionic sandwich complex Li[Pu(1,4-COT'')2 ] (3) with anhydrous cobalt(II) chloride. The first crystal structure determination of an organoplutonium(IV) complex revealed an asymmetric sandwich structure for 4 where one COT'' ring is 1,3-substit...

Mining OMIM for insight into complex diseases.

Understanding clinical phenotypes through their corresponding genotypes is one of the principal goals of genetic research. Though achieving this goal is relatively simple with single gene syndromes, more complex diseases often consist of varied clinical phenotypes that may be the result of interactions among multiple genetic loci. Microarray technology has brought the phenotype -genotype relati...

Mitophagy: New Insight into the Cardiovascular Aging  

Degradation of structurally characterized proteins injected into HeLa cells. Tests of hypotheses.

We have compared sequence and structural features of 35 proteins to their metabolic stabilities in HeLa cells. No relationship was observed between the half-life of an injected protein and its subunit molecular weight, isoelectric point, hydrophobicity, thermostability, surface charge density, or N-terminal residue. Other properties, including susceptibility to oxidation, specific combinations ...

Rare disease models provide insight into inherited forms of neurodegeneration

Hereditary spastic paraplegias (HSPs) are a group of inherited neurodegenerative conditions characterised by retrograde degeneration of the longest motor neurons in the corticospinal tract, resulting in muscle weakness and spasticity of the lower limbs. To date more than 70 genetic loci have been associated with HSP, however the majority of cases are caused by mutations that encode proteins res...